Nature Communications (Mar 2022)
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
- Hui Han,
- Chunlong Yang,
- Jieyi Ma,
- Shuishen Zhang,
- Siyi Zheng,
- Rongsong Ling,
- Kaiyu Sun,
- Siyao Guo,
- Boxuan Huang,
- Yu Liang,
- Lu Wang,
- Shuang Chen,
- Zhaoyu Wang,
- Wei Wei,
- Ying Huang,
- Hao Peng,
- Yi-Zhou Jiang,
- Junho Choe,
- Shuibin Lin
Affiliations
- Hui Han
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Chunlong Yang
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Jieyi Ma
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Shuishen Zhang
- Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University
- Siyi Zheng
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Rongsong Ling
- Institute for Advanced Study, Shenzhen University
- Kaiyu Sun
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University
- Siyao Guo
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Boxuan Huang
- Institute for Advanced Study, Shenzhen University
- Yu Liang
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Lu Wang
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Shuang Chen
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Zhaoyu Wang
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Wei Wei
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Ying Huang
- Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University
- Hao Peng
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- Yi-Zhou Jiang
- Institute for Advanced Study, Shenzhen University
- Junho Choe
- Department of Life Science, College of Natural Sciences, Hanyang University
- Shuibin Lin
- Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-022-29125-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Deregulation of METTL1-mediated N7- methylguanosine tRNA modification can promote oncogenesis. Here, the authors report that this modification regulates the translation of proteins in both the mTOR and negative regulators of autophagy pathways, resulting in the progression of esophageal squamous cell carcinoma.
