Nature Communications (Mar 2023)
Structural insights into the human niacin receptor HCA2-Gi signalling complex
- Yang Yang,
- Hye Jin Kang,
- Ruogu Gao,
- Jingjing Wang,
- Gye Won Han,
- Jeffrey F. DiBerto,
- Lijie Wu,
- Jiahui Tong,
- Lu Qu,
- Yiran Wu,
- Ryan Pileski,
- Xuemei Li,
- Xuejun Cai Zhang,
- Suwen Zhao,
- Terry Kenakin,
- Quan Wang,
- Raymond C. Stevens,
- Wei Peng,
- Bryan L. Roth,
- Zihe Rao,
- Zhi-Jie Liu
Affiliations
- Yang Yang
- iHuman Institute, ShanghaiTech University
- Hye Jin Kang
- Department of Pharmacology, and NIMH Psychoactive Drug Screening Program University of North Carolina Chapel Hill Medical School
- Ruogu Gao
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Jingjing Wang
- iHuman Institute, ShanghaiTech University
- Gye Won Han
- Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California
- Jeffrey F. DiBerto
- Department of Pharmacology, and NIMH Psychoactive Drug Screening Program University of North Carolina Chapel Hill Medical School
- Lijie Wu
- iHuman Institute, ShanghaiTech University
- Jiahui Tong
- iHuman Institute, ShanghaiTech University
- Lu Qu
- iHuman Institute, ShanghaiTech University
- Yiran Wu
- iHuman Institute, ShanghaiTech University
- Ryan Pileski
- Department of Pharmacology, and NIMH Psychoactive Drug Screening Program University of North Carolina Chapel Hill Medical School
- Xuemei Li
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Xuejun Cai Zhang
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Suwen Zhao
- iHuman Institute, ShanghaiTech University
- Terry Kenakin
- Department of Pharmacology, and NIMH Psychoactive Drug Screening Program University of North Carolina Chapel Hill Medical School
- Quan Wang
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Raymond C. Stevens
- iHuman Institute, ShanghaiTech University
- Wei Peng
- Innovation Center for Pathogen Research, Guangzhou Laboratory
- Bryan L. Roth
- Department of Pharmacology, and NIMH Psychoactive Drug Screening Program University of North Carolina Chapel Hill Medical School
- Zihe Rao
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Zhi-Jie Liu
- iHuman Institute, ShanghaiTech University
- DOI
- https://doi.org/10.1038/s41467-023-37177-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of mutation stabilized HCA2, to describe the mechanism of HCA2 signaling.
