The early stage of adult ocular dominance plasticity revealed by near-infrared optical imaging of intrinsic signals
Wei Wu,
Luwei Kang,
Yueqin Liu,
Xiao Ma,
Xinxin Zhang,
Yupeng Yang
Affiliations
Wei Wu
Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Luwei Kang
Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Yueqin Liu
Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Xiao Ma
Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Xinxin Zhang
Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Yupeng Yang
Corresponding authors at: Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
Long term monocular deprivation is considered to be necessary for the induction of significant ocular dominance plasticity in the adult visual cortex. In this study, we subjected adult mice to monocular deprivation for various durations and screened for changes in ocular dominance using dual-wavelength intrinsic signal optical imaging. We found that short-term deprivation was sufficient to cause a shift in ocular dominance and that these early-stage changes were detected only by near-infrared illumination. In addition, single-unit recordings showed that these early-stage changes primarily occurred in deep cortical layers. This early-stage ocular dominance shift was abolished by the blockade of NMDA receptors. In summary, our findings reveal an early phase of adult ocular dominance plasticity and provide the dynamics of adult plasticity.
