Nature Communications (Nov 2018)

Human adipose glycerol flux is regulated by a pH gate in AQP10

  • Kamil Gotfryd,
  • Andreia Filipa Mósca,
  • Julie Winkel Missel,
  • Sigurd Friis Truelsen,
  • Kaituo Wang,
  • Mariana Spulber,
  • Simon Krabbe,
  • Claus Hélix-Nielsen,
  • Umberto Laforenza,
  • Graça Soveral,
  • Per Amstrup Pedersen,
  • Pontus Gourdon

DOI
https://doi.org/10.1038/s41467-018-07176-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipolysis is coupled to AQP10 regulation in