Effect of Protein Corona Formation on Photonic Response of Upconverting Nanoparticles

Abstract

NaYF4:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at 545 nm and 660 nm under an excitation of 980 nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and characterized and phase transition from organic to aquas by synthesis a SiO2 shell have done successfully. The results show that the nonlinearity response of NaYF4: Yb, Er@SiO2 is same as NaYF4: Yb, Er and SiO2 has no effect on emission peaks it means that these nanoparticles are suitable for biomedical applications. Since it is necessary to know the photoluminescent behavior of UCNPs@SiO2 particles, thereby the fluorescence properties of up-conversion nanoparticles with SiO2 shell have been investigated in PBS, normal and cancerous human blood plasma. The results indicate that UCNP@SiO2 can be applicable in biological medias for therapy and diagnostic.

Keywords

• nonlinear photoresponse
• upconversion nanoparticles
• protein corona
• corona formation
• human blood plasma
• near infrared