Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators

Andrey G. Kazakov; Julia S. Babenya; Taisya Y. Ekatova; Sergey S. Belyshev; Vadim V. Khankin; Omar Albaghdadi; Alexander A. Kuznetsov; Illarion I. Dovhyi; Nikolay A. Bezhin; Ivan G. Tananaev

doi:10.3390/molecules27175532

Molecules (Aug 2022)

Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators

Andrey G. Kazakov,
Julia S. Babenya,
Taisya Y. Ekatova,
Sergey S. Belyshev,
Vadim V. Khankin,
Omar Albaghdadi,
Alexander A. Kuznetsov,
Illarion I. Dovhyi,
Nikolay A. Bezhin,
Ivan G. Tananaev

Affiliations

Andrey G. Kazakov: Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia
Julia S. Babenya: Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia
Taisya Y. Ekatova: Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia
Sergey S. Belyshev: Department of Physics, Lomonosov Moscow State University (MSU), Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia
Vadim V. Khankin: Skobeltsyn Institute of Nuclear Physics, Lomonosov MSU, Leninskie Gory, 1, Bld.2, 119991 Moscow, Russia
Omar Albaghdadi: Department of Physics, Lomonosov Moscow State University (MSU), Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia
Alexander A. Kuznetsov: Department of Physics, Lomonosov Moscow State University (MSU), Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia
Illarion I. Dovhyi: Department of Marine Biogeochemistry, Marine Hydrophysical Institute of the Russian Academy of Sciences, Kapitanskaya Str., 2, 299011 Sevastopol, Russia
Nikolay A. Bezhin: Department of Marine Biogeochemistry, Marine Hydrophysical Institute of the Russian Academy of Sciences, Kapitanskaya Str., 2, 299011 Sevastopol, Russia
Ivan G. Tananaev: Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia

DOI: https://doi.org/10.3390/molecules27175532
Journal volume & issue: Vol. 27, no. 17
p. 5532

Abstract

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In our work, the photonuclear production of 198,199Au isotopes for nuclear medicine purposes was studied, and a method for their recovery from irradiated mercury was developed. The yields of the corresponding nuclear reactions were determined, and a comparison of various methods of obtaining gold radioisotopes was provided. New sorbents based on benzo-15-crown-5, which selectively binds gold, were studied, and the optimal conditions for Au recovery with a high degree of purification from mercury were found. It was established that, for the fast and quantitative recovery of Au isotopes, it was necessary to add at least 0.1 mg of the carrier. As a result, the developed method can be regularly used to obtain 198,199Au for the research of radiopharmaceuticals based on them.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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