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-mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing

Madolyn L. MacDonald; Shawn W. Polson; Kelvin H. Lee

doi:10.1128/mSphere.01336-20

mSphere (Apr 2021)

<i>k</i> -mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing

Madolyn L. MacDonald,
Shawn W. Polson,
Kelvin H. Lee

Affiliations

Madolyn L. MacDonald: ORCiD; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA
Shawn W. Polson: ORCiD; Ammon Pinizzotto Biopharmaceutical Innovation Center, Newark, Delaware, USA
Kelvin H. Lee: ORCiD; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA

DOI: https://doi.org/10.1128/mSphere.01336-20
Journal volume & issue: Vol. 6, no. 2

Abstract

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Next-generation sequencing (NGS) has been proposed as a complementary method to detect adventitious viruses in the production of biotherapeutics and vaccines to current in vivoin vitro

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal