Frontiers in Psychiatry (Jan 2021)
Frequency-Specific Changes in the Fractional Amplitude of the Low-Frequency Fluctuations in the Default Mode Network in Medication-Free Patients With Bipolar II Depression: A Longitudinal Functional MRI Study
- Jun Zhou,
- Jun Zhou,
- Jun Zhou,
- Jun Zhou,
- Jun Zhou,
- Xiaoqian Ma,
- Xiaoqian Ma,
- Xiaoqian Ma,
- Xiaoqian Ma,
- Xiaoqian Ma,
- Chunwang Li,
- Aijun Liao,
- Aijun Liao,
- Aijun Liao,
- Aijun Liao,
- Aijun Liao,
- Zihao Yang,
- Zihao Yang,
- Zihao Yang,
- Zihao Yang,
- Zihao Yang,
- Honghong Ren,
- Honghong Ren,
- Honghong Ren,
- Honghong Ren,
- Honghong Ren,
- Jinsong Tang,
- Jinguang Li,
- Jinguang Li,
- Jinguang Li,
- Jinguang Li,
- Jinguang Li,
- Zongchang Li,
- Zongchang Li,
- Zongchang Li,
- Zongchang Li,
- Zongchang Li,
- Ying He,
- Ying He,
- Ying He,
- Ying He,
- Ying He,
- Xiaogang Chen,
- Xiaogang Chen,
- Xiaogang Chen,
- Xiaogang Chen,
- Xiaogang Chen
Affiliations
- Jun Zhou
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Jun Zhou
- National Clinical Research Center for Mental Disorders, Changsha, China
- Jun Zhou
- National Technology Institute on Mental Disorders, Changsha, China
- Jun Zhou
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Jun Zhou
- Mental Health Institute of Central South University, Changsha, China
- Xiaoqian Ma
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiaoqian Ma
- National Clinical Research Center for Mental Disorders, Changsha, China
- Xiaoqian Ma
- National Technology Institute on Mental Disorders, Changsha, China
- Xiaoqian Ma
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Xiaoqian Ma
- Mental Health Institute of Central South University, Changsha, China
- Chunwang Li
- Department of Radiology, Hunan Children's Hospital, Changsha, China
- Aijun Liao
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Aijun Liao
- National Clinical Research Center for Mental Disorders, Changsha, China
- Aijun Liao
- National Technology Institute on Mental Disorders, Changsha, China
- Aijun Liao
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Aijun Liao
- Mental Health Institute of Central South University, Changsha, China
- Zihao Yang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Zihao Yang
- National Clinical Research Center for Mental Disorders, Changsha, China
- Zihao Yang
- National Technology Institute on Mental Disorders, Changsha, China
- Zihao Yang
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Zihao Yang
- Mental Health Institute of Central South University, Changsha, China
- Honghong Ren
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Honghong Ren
- National Clinical Research Center for Mental Disorders, Changsha, China
- Honghong Ren
- National Technology Institute on Mental Disorders, Changsha, China
- Honghong Ren
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Honghong Ren
- Mental Health Institute of Central South University, Changsha, China
- Jinsong Tang
- Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
- Jinguang Li
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Jinguang Li
- National Clinical Research Center for Mental Disorders, Changsha, China
- Jinguang Li
- National Technology Institute on Mental Disorders, Changsha, China
- Jinguang Li
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Jinguang Li
- Mental Health Institute of Central South University, Changsha, China
- Zongchang Li
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Zongchang Li
- National Clinical Research Center for Mental Disorders, Changsha, China
- Zongchang Li
- National Technology Institute on Mental Disorders, Changsha, China
- Zongchang Li
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Zongchang Li
- Mental Health Institute of Central South University, Changsha, China
- Ying He
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Ying He
- National Clinical Research Center for Mental Disorders, Changsha, China
- Ying He
- National Technology Institute on Mental Disorders, Changsha, China
- Ying He
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Ying He
- Mental Health Institute of Central South University, Changsha, China
- Xiaogang Chen
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiaogang Chen
- National Clinical Research Center for Mental Disorders, Changsha, China
- Xiaogang Chen
- National Technology Institute on Mental Disorders, Changsha, China
- Xiaogang Chen
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Xiaogang Chen
- Mental Health Institute of Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fpsyt.2020.574819
- Journal volume & issue
-
Vol. 11
Abstract
Objective: This study aimed to examine the treatment-related changes of the fractional amplitude of low-frequency fluctuations (fALFF) in the default mode network (DMN) across different bands after the medication-free patients with bipolar II depression received a 16-week treatment of escitalopram and lithium.Methods: A total of 23 medication-free patients with bipolar II depression and 29 healthy controls (HCs) were recruited. We evaluated the fALFF values of slow 4 (0.027–0.073 Hz) band and slow 5 (0.01–0.027 Hz) band of the patients and compared the results with those of the 29 HCs at baseline. After 16-week treatment of escitalopram with lithium, the slow 4 and slow 5 fALFF values of the patients were assessed and compared with the baselines of patients and HCs. The depressive symptoms of bipolar II depression in patients were assessed with a 17-item Hamilton Depression Rating Scale (HDRS) before and after treatment.Results: Treatment-related effects showed increased slow 5 fALFF in cluster D (bilateral medial superior frontal gyrus, bilateral superior frontal gyrus, right middle frontal gyrus, and bilateral anterior cingulate), cluster E (bilateral precuneus/posterior cingulate, left cuneus), and cluster F (left angular, left middle temporal gyrus, left superior temporal gyrus, and left supramarginal gyrus) in comparison with the baseline of the patients. Moreover, a positive association was found between the increase in slow 5 fALFF values (follow-up value minus the baseline values) in cluster D and the decrease in HDRS scores (baseline HDRS scores minus follow-up HDRS scores) at follow-up, and the same association between the increase in slow 5 fALFF values and the decrease in HDRS scores was found in cluster E.Conclusions: The study reveals that the hypoactivity of slow 5 fALFF in the DMN is related to depression symptoms and might be corrected by the administration of escitalopram with lithium, implying that slow 5 fALFF of the DMN plays a key role in bipolar depression.
Keywords
- fractional amplitude of low-frequency fluctuations
- bipolar depression
- resting state functional magnetic resonance imaging
- default-mode Network
- escitalopram
- lithium
