A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL

Mateo Mejia Saldarriaga; Amir Steinberg; Eric A. Severson; Adam Binder

doi:10.3389/fonc.2019.01303

Frontiers in Oncology (Dec 2019)

A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL

Mateo Mejia Saldarriaga,
Amir Steinberg,
Eric A. Severson,
Adam Binder

Affiliations

Mateo Mejia Saldarriaga: Albert Einstein College of Medicine/Jacobi Medical Center, The Bronx, NY, United States
Amir Steinberg: Department of Oncology, Mount Sinai Hospital, New York, NY, United States
Eric A. Severson: Foundation Medicine, Morrisville, NC, United States
Adam Binder: Department of Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States

DOI: https://doi.org/10.3389/fonc.2019.01303
Journal volume & issue: Vol. 9

Abstract

Read online

We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the CCDC6 and RET genes. Although the RET mutations have been identified before in other malignancies, and it is thought to represent a driver mutation in these neoplasms, it has yet to be described in ALL. The identification of known fusion genes conferring activating tyrosine kinase activity in neoplasms can suggest potential therapeutic role of tyrosine kinase inhibitors (TKI), an approach that has been exploited in several other fusion genes.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords