Study Of Detection Of Serum CXCL10 In Vitiligo Patients

Abstract

The goal of this study was to detect the level of CXCL10 in the serum of the vitiligo patients as compared to the normal control persons to investigate the possible role of CXCL10 in the pathogenesis of this disease. The present study included 30 Egyptian vitiligo patients, their age ranged from (20 to 50 years). They were recruited fromDermatology outpatient clinic at Beni-Suef University hospital. Thirty unrelated apparent healthy controls with similar demographic (matched age and sex) were taken during the period from (1st May 2018 to 1st May 2019).5ml blood sample was taken from patients and controls and was left to clot for 30 minutes then serum was separated by centrifugation and kept frozen at -80c till analysis of CXCL10 by ELISA. The patients and controls were subjected to estimation of the serum level of CXCL10. The result of the study showed that increased levels of CXCL10 in the vitiligo patients when compared to controls and the patients in the progressive stage showed higher expression of CXCL10 than those in the stable stage, suggesting a mechanistic role of CXCL10 in vitiligo.

Keywords

• vitiligo
• t cell immune response
• ifn-γ
• cxcl-10