Mechanism of immune evasion in breast cancer

Abstract

Mozhi Wang,1,* Changwang Zhang,2,* Yongxi Song,2 Zhenning Wang,2 Yaojia Wang,1 Fang Luo,1 Yujie Xu,1 Yi Zhao,1 Zhonghua Wu,2 Yingying Xu1 1Department of Breast Surgery, 2Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China *These authors contributed equally to this work Abstract: Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body’s immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail. Keywords: immune evasion, mechanism, breast cancer, cytokines, apoptosis, PD-L1

Keywords

• Immune evasion
• mechanism
• breast cancer
• cytokines
• apoptosis
• PD-L1