Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Helen Bolton; Sarah J. L. Graham; Niels Van der Aa; Parveen Kumar; Koen Theunis; Elia Fernandez Gallardo; Thierry Voet; Magdalena Zernicka-Goetz

doi:10.1038/ncomms11165

Nature Communications (Mar 2016)

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Helen Bolton,
Sarah J. L. Graham,
Niels Van der Aa,
Parveen Kumar,
Koen Theunis,
Elia Fernandez Gallardo,
Thierry Voet,
Magdalena Zernicka-Goetz

Affiliations

Helen Bolton: Department of Physiology, Development and Neuroscience and Gurdon Institute, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Sarah J. L. Graham: Department of Physiology, Development and Neuroscience and Gurdon Institute, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Niels Van der Aa: Department of Human Genetics, University of Leuven, KU Leuven
Parveen Kumar: Department of Human Genetics, University of Leuven, KU Leuven
Koen Theunis: Department of Human Genetics, University of Leuven, KU Leuven
Elia Fernandez Gallardo: Department of Human Genetics, University of Leuven, KU Leuven
Thierry Voet: Department of Human Genetics, University of Leuven, KU Leuven
Magdalena Zernicka-Goetz: Department of Physiology, Development and Neuroscience and Gurdon Institute, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK

DOI: https://doi.org/10.1038/ncomms11165
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploid cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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