DNA-Aeon provides flexible arithmetic coding for constraint adherence and error correction in DNA storage

Marius Welzel; Peter Michael Schwarz; Hannah F. Löchel; Tolganay Kabdullayeva; Sandra Clemens; Anke Becker; Bernd Freisleben; Dominik Heider

doi:10.1038/s41467-023-36297-3

Nature Communications (Feb 2023)

DNA-Aeon provides flexible arithmetic coding for constraint adherence and error correction in DNA storage

Marius Welzel,
Peter Michael Schwarz,
Hannah F. Löchel,
Tolganay Kabdullayeva,
Sandra Clemens,
Anke Becker,
Bernd Freisleben,
Dominik Heider

Affiliations

Marius Welzel: Department of Mathematics and Computer Science, University of Marburg
Peter Michael Schwarz: Department of Mathematics and Computer Science, University of Marburg
Hannah F. Löchel: Department of Mathematics and Computer Science, University of Marburg
Tolganay Kabdullayeva: Center for Synthetic Microbiology (SYNMIKRO), University of Marburg
Sandra Clemens: Department of Mathematics and Computer Science, University of Marburg
Anke Becker: Center for Synthetic Microbiology (SYNMIKRO), University of Marburg
Bernd Freisleben: Department of Mathematics and Computer Science, University of Marburg
Dominik Heider: Department of Mathematics and Computer Science, University of Marburg

DOI: https://doi.org/10.1038/s41467-023-36297-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

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The extensive information capacity of DNA makes it an attractive alternative to traditional data storage. DNA-Aeon is a DNA data storage solution that can correct all error types commonly observed in DNA storage, while encoding data into sequences that meet user-defined constraints such as GC content, homopolymer length, and no undesired motifs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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