Vascular Endothelial Growth Factor: Genetic Aspects in Children with Asthma in the Rostov Region

Abstract

Vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of asthma. It activates neoangiogenesis, thus contributing to disruption of the microcirculation in the bronchi and increasing the intensity of exposure to the elements of the inflammatory cascade. So, the goal of this research was to evaluate the role of C-634G VEGFA gene polymorphism in the pathogenesis of childhood asthma. In the analysis of the blood no statistically significant differences has been revealed in the genotype frequencies and allele on investigated polymorphism between the control group of children and the group of children with asthma. The most frequently registered one is homozygous polymorphism of VEGFA gene. The influence of the polymorphic C-634G of VEGFA gene on the concentration of serum IgE is not revealed.

Keywords

• Asthma
• Vascular endothelial growth factor
• Gene polymorphism
• Children