Nature Communications (Feb 2022)

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis

  • Diego J. Páez-Moscoso,
  • David V. Ho,
  • Lili Pan,
  • Katie Hildebrand,
  • Kristi L. Jensen,
  • Michaella J. Levy,
  • Laurence Florens,
  • Peter Baumann

DOI
https://doi.org/10.1038/s41467-022-28545-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Most eukaryotes maintain telomeres using a specialized reverse transcriptase. Here the authors report that Thc1 (Telomerase Holoenzyme Component 1) and Bmc1 (Bin3/MePCE 1) form a complex with Pof8, a constitutive member of telomerase in fission yeast.