High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection

Erica Normandin; Melissa Rudy; Nikolaos Barkas; Stephen F. Schaffner; Zoe Levine; Robert F. Padera; Mehrtash Babadi; Shibani S. Mukerji; Daniel J. Park; Bronwyn L. MacInnis; Katherine J. Siddle; Pardis C. Sabeti; Isaac H. Solomon

doi:10.1038/s41467-022-34256-y

Nature Communications (Feb 2023)

High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection

Erica Normandin,
Melissa Rudy,
Nikolaos Barkas,
Stephen F. Schaffner,
Zoe Levine,
Robert F. Padera,
Mehrtash Babadi,
Shibani S. Mukerji,
Daniel J. Park,
Bronwyn L. MacInnis,
Katherine J. Siddle,
Pardis C. Sabeti,
Isaac H. Solomon

Affiliations

Erica Normandin: Broad Institute of Harvard and MIT
Melissa Rudy: Broad Institute of Harvard and MIT
Nikolaos Barkas: Broad Institute of Harvard and MIT
Stephen F. Schaffner: Broad Institute of Harvard and MIT
Zoe Levine: Broad Institute of Harvard and MIT
Robert F. Padera: Department of Pathology, Brigham and Women’s Hospital
Mehrtash Babadi: Broad Institute of Harvard and MIT
Shibani S. Mukerji: Department of Neurology, Massachusetts General Hospital
Daniel J. Park: Broad Institute of Harvard and MIT
Bronwyn L. MacInnis: Broad Institute of Harvard and MIT
Katherine J. Siddle: Broad Institute of Harvard and MIT
Pardis C. Sabeti: Broad Institute of Harvard and MIT
Isaac H. Solomon: Department of Pathology, Brigham and Women’s Hospital

DOI: https://doi.org/10.1038/s41467-022-34256-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al. investigate viral dynamics in fatal cases of COVID-19, revealing persistent infection in distinct anatomical sites, including the heart and testis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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