A PRELIMINARY STUDY OF THE EFFECT OF ANESTHETIC AGENTS ON THERHEOLOGICAL PARAMETERS OF GLYCATED ERYTHROCYTES

Abstract

This paper presents a preliminary study of the effects of the anesthetics propofol, remifentanil, and vecuronium bromideon the rheological properties of glycated erythrocytes in vitro, modeling the glycation by hyperglycemia observed in diabetes. Viscoelastic and aggregation kinetic parameters of erythrocytes were determined using an erythrocyterheometer and an optical chip aggregometer developed in our laboratory. The results showed significant alterations in the membrane surface viscosity, the elastic modulus, and the erythrocyte deformability index for the different anesthetics studied. Also, the kinetics aggregation parameters showed different types of alterations due to the effect of anesthetics. This preliminary study suggests that the use of these anesthetics in diabetic patients could induce hemorheological alterations that disturb the microcirculation. For this reason, it is recommended to deepen these investigations to prevent complications in surgical procedures.

Keywords

• viscoelasticity
• erythrocyte aggregation
• glycation
• anesthetics
• diabetes