Polyoxometalate-based heterojunction with NIR light-facilitated photocatalytic W6+/W5+ redox cycling for enhanced bacteria-infected wound healing

Mingzhu Lv; Zhou Xu; Yuan Yong; Huan Wang; Chenghui Liu; Qiqi Xu; Guobo Du; Jiani Xie; Yong You; Jiangwei Xiao; Guohui Jiang

Materials & Design (Feb 2023)

Polyoxometalate-based heterojunction with NIR light-facilitated photocatalytic W6+/W5+ redox cycling for enhanced bacteria-infected wound healing

Mingzhu Lv,
Zhou Xu,
Yuan Yong,
Huan Wang,
Chenghui Liu,
Qiqi Xu,
Guobo Du,
Jiani Xie,
Yong You,
Jiangwei Xiao,
Guohui Jiang

Affiliations

Mingzhu Lv: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
Zhou Xu: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu 610500, China
Yuan Yong: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Corresponding authors at: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China (Y. Yong).
Huan Wang: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
Chenghui Liu: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
Qiqi Xu: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
Guobo Du: Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
Jiani Xie: College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, China
Yong You: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
Jiangwei Xiao: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu 610500, China; Corresponding authors at: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China (Y. Yong).
Guohui Jiang: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Institute of neurological diseases, North Sichuan Medical College, Nanchong 637000, China; Corresponding authors at: Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China (Y. Yong).

Journal volume & issue: Vol. 226
p. 111673

Abstract

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Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) with shifting or mixed redox states (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation by near-infrared (NIR) laser-facilitated W6+/W5+ redox cycling for accelerated bacteria-infected wound healing. On the one hand, under the exposure to NIR laser, WS2 as electron donor could be stimulated to transfer electrons to GdP5W30, which promotes the reduction from W6+ to W5+ active sites on the surface of the GdP5W30. Consequently, the regenerated W5+ active sites could catalyze endogenous overexpressed H2O2 to persistently generate ROS, which displays enhanced POD-like catalytic activity for chemodynamic therapy (CDT) by NIR-driven photocatalytic W6+/W5+ redox cycling. Moreover, GdP5W30@WS2 also displays favorable glutathione (GSH)-activated photothermal performance by W6+-triggered GSH exhaustion for sufficient ROS generation, thereby facilitating the synergistic therapeutic efficiency of photothermal therapy (PTT) and CDT. We expect that the present work will promote the development of the heterojunction with shifting or mixed redox states for biofilm elimination based on NIR-facilitated enzyme-like catalytic activity, which may act as a candidate for BME-activated synergistic therapy.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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