Metformin and Renal Protection

Abstract

Metformin as a biguanid drug entered to the market 50 years ago, and now is generally recommended as the first-line treatment of type 2 diabetes mellitus, especially in overweight patients. However, in recent years ,new indications for its use have found. Recently, much attention has been directed toward the possible renal protective efficiency of metformin. Recent studies have proven that metformin, possesses antioxidant efficacy as well. Reduction of apoptosis, induced by oxidative stress in endothelial cells and prevention of vascular dysfunction is found with metformin treatment, too.

Keywords

• Metformin
• Renal protection
• Oxidative stress
• Antioxidant