Nature Communications (Oct 2018)
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
- Suzana A. Kahn,
- Xin Wang,
- Ryan T. Nitta,
- Sharareh Gholamin,
- Johanna Theruvath,
- Gregor Hutter,
- Tej D. Azad,
- Lina Wadi,
- Sara Bolin,
- Vijay Ramaswamy,
- Rogelio Esparza,
- Kun-Wei Liu,
- Michael Edwards,
- Fredrik J. Swartling,
- Debashis Sahoo,
- Gordon Li,
- Robert J. Wechsler-Reya,
- Jüri Reimand,
- Yoon-Jae Cho,
- Michael D. Taylor,
- Irving L. Weissman,
- Siddhartha S. Mitra,
- Samuel H. Cheshier
Affiliations
- Suzana A. Kahn
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Xin Wang
- Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto
- Ryan T. Nitta
- Department of Neurosurgery, Stanford University School of Medicine
- Sharareh Gholamin
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Johanna Theruvath
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Gregor Hutter
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Tej D. Azad
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Lina Wadi
- Computational Biology Program, Ontario Institute for Cancer Research
- Sara Bolin
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Vijay Ramaswamy
- Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto
- Rogelio Esparza
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Kun-Wei Liu
- Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute
- Michael Edwards
- Department of Neurosurgery, Stanford University School of Medicine
- Fredrik J. Swartling
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University
- Debashis Sahoo
- Department of Pediatrics and Department of Computer Science and Engineering, University of California San Diego
- Gordon Li
- Department of Neurosurgery, Stanford University School of Medicine
- Robert J. Wechsler-Reya
- Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute
- Jüri Reimand
- Computational Biology Program, Ontario Institute for Cancer Research
- Yoon-Jae Cho
- Ludwig Institute for Cancer Research, Stanford University School of Medicine
- Michael D. Taylor
- Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto
- Irving L. Weissman
- Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine
- Siddhartha S. Mitra
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- Samuel H. Cheshier
- Division of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06564-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models a NOTCH1 blocking antibody decreased spinal metastases.
