Study The Effect of Ketoconazole and Vitamin E on Some Arabi Ram Sperm Characteristics

Abstract

      Experiment  aims to investigate the effect of ketoconazole on certain sperm characteristic of Arabi rams .fifteen adult rams were randomly assigned in 3 groups, 5 animals in each group which treated daily as the following : control group, ket group received orally (25 mg/kg body weight of ketoconazole and ket-E group received (25 mg/kg body weight of ketoconazole+50 mg vit E / head). The study lasted 28 days.  Collection of semen was done each week by artificial vagina. Sperm traits were estimated in addition to assessment the level of testosterone and some anti_oxidative enzyme and oxidative marker (MDA ). It was concluded that orally administered Ketoconazole has a negative impact on fertility of Arabi rams and vit E at 50 mg/head can prevent adverse effect of ketoconazole on sperm characteristic of Arabi rams.

Keywords

• ketoconazole
• vit e
• arabi rams