A rare case report of primary bone lymphoma and a brief review of the literature

Abstract

Jia Wang,1,2 Shouren Fan,1,3 Jie Liu,2 Bao Song4 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 2Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, 3Department of Intervention, Qihe People’s Hospital, 4Elementary Laboratory, Shandong Cancer Hospital affiliated to Shandong University, Jinan, People’s Republic of China Abstract: Primary bone lymphoma is a rare and peculiar extranodal presentation of non-Hodgkin’s lymphoma, which threatens human health. It can be defined as a lymphoma that occurs in the bone, consisting of a single bone lesion with or without regional lymphadenopathies, and its underlying causes are largely unknown. In this case report, we describe a male who presented with left-sided distal forearm pain, swelling of 2 months duration, and progressive limited wrist motion for about 1 month. The patient had no significant medical history except diabetes. Magnetic Resonance Imaging demonstrated a sheet-like bone destruction area in the left-sided radius, localized discontinuous bone cortex, and adjacent soft tissue masses. Finally, a bone biopsy examined by histopathological and immunochemical methods confirmed a diagnosis of primary bone diffuse large B-cell lymphoma. Due to the rarity of this disease, the level of evidence supporting some diagnostic and therapeutic decisions remains low, and therefore, the details of the rare case may facilitate treatment of similar diseases and provide insight about this obscure lymphoproliferative malignancy. Also, related recent literature reports of primary bone lymphoma are reviewed. Keywords: DLBCL, diffuse large B-cell lymphoma, primary DLBCL bone lymphoma, radius, consolidation radiotherapy, rituximab

Keywords

• primary bone lymphoma
• radius
• consolidation radiotherapy
• rituximab