Serum Lipid Profile in Pre and Post Cholecystectomy Patients

Abstract

Introduction: Gall stones are common in western world with an incidence of 1.4 per 100 person per year. Based on evidence more than 50% of patients with gallstones have some sort of lipid disorder. Cholecystectomy causes redistribution of bile acid pool in the entero-hepatic circulation and increases the frequency of cycling cause reduction in pool size thus exerting effect on lipid profile decreasing total cholesterol and LDL cholesterol levels. Aim: Evaluating lipid profile of patients with gall stone pre- and post operatively on 7th day and one month and to establish the effect of cholecystectomy on lipid profile. Materials and Methods: This prospective observational study included 60 patients of gall stones admitted to Surgery Department of Rajindra Hospital Patiala from July 2014 to June 2016 and who underwent cholecystectomy. The lipid profile was evaluated pre-operatively on the day of operation and post operatively on 7th day and one month after. Results: The total serum lipid pre-operatively was mean value of 553.47±140.86 mg% which increased to 562.58±103.17 mg% on the 7th day and then decreased to 518.53±86.76 mg% one month post-operatively. Serum triglycerides level increased initially to 159.47±43.32 mg% on 7th day and then decreased significantly from mean value of 143.63±69.05 mg% to 139.60±60 mg% one month post-operatively. There was significant decrease in total serum cholesterol from pre-operative mean value of 193.17±58.84 mg% to 186.3±56.71 mg% on 7th day and further decreased to 166.95±48.08 mg% one month post-operatively. Total serum LDL cholesterol level decreased significantly from pre-operative mean value of 153.90±43.44 mg% to 132.08±36.93 mg% on 7th day and decreased further to 117.52±29.00 mg% one month post operatively. The serum HDL cholesterol level increased significantly from pre-operative level of 41.35±5.4 mg% to 43.27±6.3 mg% on 7th day and further to 54.10±8.5 mg% one month post-operatively. Majority of patients had mixed type of gall stones. Conclusion: Total serum lipids, serum cholesterol, serum LDL cholesterol and serum triglycerides levels decrease and serum HDL cholesterol increase after cholecystectomy

Keywords

• biliary calculi
• cholesterol
• triglycerides