Working memory deficit in drug-resistant epilepsy with an amygdala lesion

Keiko Usui; Kiyohito Terada; Naotaka Usui; Kazumi Matsuda; Akihiko Kondo; Takayasu Tottori; Jun Shinozaki; Takashi Nagamine; Yushi Inoue

Epilepsy and Behavior Case Reports (Jan 2018)

Working memory deficit in drug-resistant epilepsy with an amygdala lesion

Keiko Usui,
Kiyohito Terada,
Naotaka Usui,
Kazumi Matsuda,
Akihiko Kondo,
Takayasu Tottori,
Jun Shinozaki,
Takashi Nagamine,
Yushi Inoue

Affiliations

Keiko Usui: Department of Systems Neuroscience, School of Medicine, Sapporo Medical University, Japan; Corresponding author at: Department of Systems Neuroscience, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan.
Kiyohito Terada: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Naotaka Usui: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Kazumi Matsuda: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Akihiko Kondo: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Takayasu Tottori: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Jun Shinozaki: Department of Systems Neuroscience, School of Medicine, Sapporo Medical University, Japan
Takashi Nagamine: Department of Systems Neuroscience, School of Medicine, Sapporo Medical University, Japan
Yushi Inoue: National Hospital Organization, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan

Journal volume & issue: Vol. 10
pp. 86 – 91

Abstract

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This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere.The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluorodeoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited to the right uncus for the TLE-AL group.The results suggest the importance of considering cognitive functions in the non-dominant hemisphere to prevent impairment after surgery. Keywords: Amygdala lesion, Temporal lobe epilepsy, Cognitive functions, Working memory

Published in Epilepsy and Behavior Case Reports

ISSN: 2213-3232 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.journals.elsevier.com/epilepsy-and-behavior-case-reports/

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