Nature Communications (Dec 2016)
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
- Petter Holland,
- Helene Knævelsrud,
- Kristiane Søreng,
- Benan J. Mathai,
- Alf Håkon Lystad,
- Serhiy Pankiv,
- Gunnveig T. Bjørndal,
- Sebastian W. Schultz,
- Viola H. Lobert,
- Robin B. Chan,
- Bowen Zhou,
- Knut Liestøl,
- Sven R. Carlsson,
- Thomas J. Melia,
- Gilbert Di Paolo,
- Anne Simonsen
Affiliations
- Petter Holland
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Helene Knævelsrud
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Kristiane Søreng
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Benan J. Mathai
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Alf Håkon Lystad
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Serhiy Pankiv
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Gunnveig T. Bjørndal
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Sebastian W. Schultz
- Faculty of Medicine and Department of Molecular Cell Biology, Centre for Cancer Biomedicine, Institute for Cancer Research, Oslo University Hospital
- Viola H. Lobert
- Faculty of Medicine and Department of Molecular Cell Biology, Centre for Cancer Biomedicine, Institute for Cancer Research, Oslo University Hospital
- Robin B. Chan
- Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center
- Bowen Zhou
- Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center
- Knut Liestøl
- Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo
- Sven R. Carlsson
- Thomas J. Melia
- Department of Cell Biology, Yale University School of Medicine
- Gilbert Di Paolo
- Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center
- Anne Simonsen
- Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- DOI
- https://doi.org/10.1038/ncomms13889
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization of the PA-producing enzyme phospholipase D1.
