Frontiers in Human Neuroscience (May 2023)
Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial
- Patricio Solis-Urra,
- Patricio Solis-Urra,
- Patricio Solis-Urra,
- Cristina Molina-Hidalgo,
- Cristina Molina-Hidalgo,
- Yolanda García-Rivero,
- Yolanda García-Rivero,
- Claudia Costa-Rodriguez,
- Jose Mora-Gonzalez,
- Beatriz Fernandez-Gamez,
- Marcos Olvera-Rojas,
- Andrea Coca-Pulido,
- Angel Toval,
- Darío Bellón,
- Alessandro Sclafani,
- Isabel Martín-Fuentes,
- Eva María Triviño-Ibañez,
- Eva María Triviño-Ibañez,
- Carlos de Teresa,
- Haiqing Huang,
- George Grove,
- Charles H. Hillman,
- Charles H. Hillman,
- Charles H. Hillman,
- Arthur F. Kramer,
- Arthur F. Kramer,
- Andrés Catena,
- Francisco B. Ortega,
- Francisco B. Ortega,
- Francisco B. Ortega,
- Manuel Gómez-Río,
- Manuel Gómez-Río,
- Kirk I. Erickson,
- Kirk I. Erickson,
- Irene Esteban-Cornejo,
- Irene Esteban-Cornejo,
- Irene Esteban-Cornejo
Affiliations
- Patricio Solis-Urra
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Patricio Solis-Urra
- Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain
- Patricio Solis-Urra
- Faculty of Education and Social Sciences, Universidad Andrés Bello, Viña del Mar, Chile
- Cristina Molina-Hidalgo
- Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
- Cristina Molina-Hidalgo
- AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, United States
- Yolanda García-Rivero
- Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain
- Yolanda García-Rivero
- ibs.GRANADA Instituto de Investigación Biosanitaria, Granada, Spain
- Claudia Costa-Rodriguez
- Dirección de Seleccion y Admisión de Alumnos, Universidad de Playa Ancha, Valparaíso, Chile
- Jose Mora-Gonzalez
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Beatriz Fernandez-Gamez
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Marcos Olvera-Rojas
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Andrea Coca-Pulido
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Angel Toval
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Darío Bellón
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Alessandro Sclafani
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Isabel Martín-Fuentes
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Eva María Triviño-Ibañez
- Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain
- Eva María Triviño-Ibañez
- ibs.GRANADA Instituto de Investigación Biosanitaria, Granada, Spain
- Carlos de Teresa
- Andalusian Centre of Sports Medicine, Consejería de Turismo y Deporte, Granada, Spain
- Haiqing Huang
- Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
- George Grove
- Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
- Charles H. Hillman
- Center for Cognitive and Brain Health, Northeastern University, Boston, MA, United States
- Charles H. Hillman
- 0Department of Psychology, Northeastern University, Boston, MA, United States
- Charles H. Hillman
- 1Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States
- Arthur F. Kramer
- Center for Cognitive and Brain Health, Northeastern University, Boston, MA, United States
- Arthur F. Kramer
- 2Beckman Institute, University of Illinois, Urbana, IL, United States
- Andrés Catena
- 3School of Psychology, University of Granada, Granada, Spain
- Francisco B. Ortega
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Francisco B. Ortega
- 4Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
- Francisco B. Ortega
- 5Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
- Manuel Gómez-Río
- Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain
- Manuel Gómez-Río
- ibs.GRANADA Instituto de Investigación Biosanitaria, Granada, Spain
- Kirk I. Erickson
- Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
- Kirk I. Erickson
- AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, United States
- Irene Esteban-Cornejo
- Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain
- Irene Esteban-Cornejo
- ibs.GRANADA Instituto de Investigación Biosanitaria, Granada, Spain
- Irene Esteban-Cornejo
- 5Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
- DOI
- https://doi.org/10.3389/fnhum.2023.1168549
- Journal volume & issue
-
Vol. 17
Abstract
Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.
Keywords
