RMD Open (Dec 2022)
Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients
- Ricardo Blanco,
- Alfredo Adan,
- Ignacio Torre,
- Vega Jovani,
- Susana Romero-Yuste,
- Arantxa Conesa,
- Vanesa Calvo-Río,
- Cristina Fernández-Carballido,
- Emma Beltrán-Catalán,
- Patricia Fanlo,
- Miguel Cordero-Coma,
- Alvaro Garcia Martos,
- Ines Hernanz,
- Angel Garcia-Aparicio,
- Patricia Moya Alvarado,
- José Luis Martín-Varillas,
- Lara Sanchez-Bilbao,
- Adela Gallego-Flores,
- Sonia Castro-Oreiro,
- Juan Ramon De Dios,
- Marisa Hernández-Garfella,
- Amalia Sánchez-Andrade,
- Andrea García-Valle,
- Olga Maiz,
- Roberto Miguélez,
- Sergio Rodríguez-Montero,
- Ana Urruticoechea,
- Raúl Veroz,
- Jose J Mondejar,
- Olga Martínez González,
- Paula Rubio-Muñoz,
- Eva Peña-Sainz-Pardo,
- Marta Garijo-Bufort,
- Rosalía Demetrio-Pablo,
- José L Hernández
Affiliations
- Ricardo Blanco
- 3 Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain
- Alfredo Adan
- Ophthalmology Department, Hospital Clinic, Barcelona, Spain
- Ignacio Torre
- 1Rheumatology Dept., Basurto University Hospital, Bilbao
- Vega Jovani
- 1 Seccion de Reumatologia, Hospital General Universitario de Alicante, Alicante, Spain
- Susana Romero-Yuste
- Reference hospitals, Rheumatology, Internal Medicine and Pathology Units, Spain, Spain
- Arantxa Conesa
- Reference hospitals, Rheumatology, Internal Medicine and Pathology Units, Spain, Spain
- Vanesa Calvo-Río
- Reference hospitals, Rheumatology, Internal Medicine and Pathology Units, Spain, Spain
- Cristina Fernández-Carballido
- Rheumatology Unit, Hospital General de Elda, Elda, Spain
- Emma Beltrán-Catalán
- Rheumatology, Hospital del Mar, Barcelona, Spain
- Patricia Fanlo
- 10 Servicio de Medicina Interna, H. Virgen del Camino, Pamplona, Spain
- Miguel Cordero-Coma
- 2Ophthalmology Department, Hospital de León, IBIOMED, Universidad de León, León, Spain
- Alvaro Garcia Martos
- Division of Rheumatology, Hospital Universitario del Tajo, Aranjuez, Spain
- Ines Hernanz
- Ophthalmology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
- Angel Garcia-Aparicio
- Department of Rheumatology, Hospital Universitario de Toledo, Toledo, Spain
- Patricia Moya Alvarado
- Rheumatology Department, Hospital de la Santa Creu i Sant Pau Barcelona, Barcelona, Spain
- José Luis Martín-Varillas
- Rheumatology, Hospital Comarcal de Laredo, Laredo, Spain
- Lara Sanchez-Bilbao
- Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
- Adela Gallego-Flores
- Rheumatology, University Hospital Complex Badajoz, Badajoz, Spain
- Sonia Castro-Oreiro
- Rheumatology, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
- Juan Ramon De Dios
- Department of Rheumatology, Araba University Hospital, Vitoria-Gasteiz, Spain
- Marisa Hernández-Garfella
- Ophthalmology, General University Hospital Consortium of Valencia, Valencia, Spain
- Amalia Sánchez-Andrade
- Rheumatology, University Hospital Lucus Augusti, Lugo, Spain
- Andrea García-Valle
- Rheumatology, Complejo Asistencial de Palencia, Palencia, Spain
- Olga Maiz
- Rheumatology, Hospital of Donostia, San Sebastian, Spain
- Roberto Miguélez
- Rheumatology, Hospital Universitario de Mostoles, Mostoles, Spain
- Sergio Rodríguez-Montero
- Rheumatology, Hospital Virgen de Valme, Sevilla, Spain
- Ana Urruticoechea
- Rheumatology, Hospital Can Misses, Eivissa, Illes Balears, Spain
- Raúl Veroz
- Rheumatology, Hospital de Merida, Merida, Spain
- Jose J Mondejar
- Ophthalmology, Hospital General Universitario de Alicante, Alicante, Spain
- Olga Martínez González
- Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain
- Paula Rubio-Muñoz
- Rheumatology, Fundació Hospital de l`Esperit Sant, Barcelona, Spain
- Eva Peña-Sainz-Pardo
- Pediatric, Hospital Universitario 12 de Octubre, Madrid, Spain
- Marta Garijo-Bufort
- Rheumatology, Hospital de Sagunto, Sagunto, Spain
- Rosalía Demetrio-Pablo
- Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
- José L Hernández
- Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
- DOI
- https://doi.org/10.1136/rmdopen-2022-002693
- Journal volume & issue
-
Vol. 8,
no. 2
Abstract
Objectives To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID).Methods Multicentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year.Results We studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6±11.7 years. The IMID included were: spondyloarthritis (n=43), Behçet’s disease (n=10), psoriatic arthritis (n=8), Crohn’s disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1),Conclusions CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.
