Nature Communications (Apr 2020)
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
- Ji Young Kim,
- Yuntao Bai,
- Laura A. Jayne,
- Ralph D. Hector,
- Avinash K. Persaud,
- Su Sien Ong,
- Shreshtha Rojesh,
- Radhika Raj,
- Mei Ji He Ho Feng,
- Sangwoon Chung,
- Rachel E. Cianciolo,
- John W. Christman,
- Moray J. Campbell,
- David S. Gardner,
- Sharyn D. Baker,
- Alex Sparreboom,
- Rajgopal Govindarajan,
- Harpreet Singh,
- Taosheng Chen,
- Ming Poi,
- Katalin Susztak,
- Stuart R. Cobb,
- Navjot Singh Pabla
Affiliations
- Ji Young Kim
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Yuntao Bai
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Laura A. Jayne
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Ralph D. Hector
- Simons Initiative for the Developing Brain & Patrick Wild Centre, Centre for Discovery Brain Sciences, University of Edinburgh
- Avinash K. Persaud
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Su Sien Ong
- Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital
- Shreshtha Rojesh
- Renal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of Pennsylvania
- Radhika Raj
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Mei Ji He Ho Feng
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Sangwoon Chung
- Pulmonary, Sleep and Critical Care Medicine, Wexner Medical Center, Davis Heart and Lung Research Institute
- Rachel E. Cianciolo
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- John W. Christman
- Pulmonary, Sleep and Critical Care Medicine, Wexner Medical Center, Davis Heart and Lung Research Institute
- Moray J. Campbell
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- David S. Gardner
- School of Veterinary Medicine and Science, University of Nottingham
- Sharyn D. Baker
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Alex Sparreboom
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Rajgopal Govindarajan
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Harpreet Singh
- Department of Physiology and Cell Biology and Davis Heart and Lung Research Institute, The Ohio State University
- Taosheng Chen
- Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital
- Ming Poi
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- Katalin Susztak
- Renal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of Pennsylvania
- Stuart R. Cobb
- Simons Initiative for the Developing Brain & Patrick Wild Centre, Centre for Discovery Brain Sciences, University of Edinburgh
- Navjot Singh Pabla
- Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-020-15638-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.
