Effect of Sustained Administration of Thymol on Its Bioaccessibility and Bioavailability in Rabbits

Abstract

The objective of this study was the detection of thymol in rabbit plasma, tissues, large intestinal content, and faeces. Forty-eight rabbits were divided into control and experimental groups (thymol 250 mg/kg feed). Thymol was administered for 21 days and then withdrawn for 7 days. Concentration of thymol in the intestinal wall (IW) was significantly higher than in plasma (p p p p p s = −1.000, p s = 0.786, p s = 0.738, p p < 0.01). Results show intensive biotransformation of thymol in the rabbit organism.

Keywords

• rabbit
• thymol
• absorption
• distribution
• accumulation
• excretion