Nature Communications (Nov 2019)
Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
- Priyanka Gopal,
- Elif Irem Sarihan,
- Eui Kyu Chie,
- Gwendolyn Kuzmishin,
- Semihcan Doken,
- Nathan A. Pennell,
- Daniel P. Raymond,
- Sudish C. Murthy,
- Usman Ahmad,
- Siva Raja,
- Francisco Almeida,
- Sonali Sethi,
- Thomas R. Gildea,
- Craig D. Peacock,
- Drew J. Adams,
- Mohamed E. Abazeed
Affiliations
- Priyanka Gopal
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- Elif Irem Sarihan
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- Eui Kyu Chie
- 101, Daehak-Ro, Jongno-Gu, Department of Radiation Oncology, Seoul National University College of Medicine
- Gwendolyn Kuzmishin
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- Semihcan Doken
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- Nathan A. Pennell
- 10201 Carnegie Ave/CA-5, Department of Hematology and Medical Oncology, Cleveland Clinic
- Daniel P. Raymond
- 9500 Euclid Avenue/J4-1, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
- Sudish C. Murthy
- 9500 Euclid Avenue/J4-1, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
- Usman Ahmad
- 9500 Euclid Avenue/J4-1, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
- Siva Raja
- 9500 Euclid Avenue/J4-1, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
- Francisco Almeida
- 9500 Euclid Avenue/M2-141, Department of Pulmonary Medicine, Cleveland Clinic
- Sonali Sethi
- 9500 Euclid Avenue/M2-141, Department of Pulmonary Medicine, Cleveland Clinic
- Thomas R. Gildea
- 9500 Euclid Avenue/M2-141, Department of Pulmonary Medicine, Cleveland Clinic
- Craig D. Peacock
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- Drew J. Adams
- 2109 Adelbert Road/BRB, Case Western Reserve University, Department of Genetics
- Mohamed E. Abazeed
- 2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic
- DOI
- https://doi.org/10.1038/s41467-019-13161-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.
