Retrospective study to compare the outcomes of matched related donor vs matched unrelated donor in patient with acute myeloid leukaemia

Abstract

Background: India's need for bone marrow donation and transplantation is increasing in the context of the rising incidence of haematological neoplasms like acute myeloid leukaemia (AML). The use of matched related donors (MRD) for hematopoietic stem cell transplantation (HSCT) is a feasible option, but the lack of HLA-matched donors in India remains a significant obstacle to successful treatment. Methodology: This retrospective study was conducted at the Department of Hemato-Oncology & Bone Marrow Transplant, Rajiv Gandhi Cancer Institute in New Delhi, India over a period of 6 months. The study enrolled 77 AML MRD and 19 AML MUD patients based on the inclusion and exclusion criteria. Result: The one-year survival rate was higher in MRD than in MUD, but there was no significant difference in mortality in multivariate analysis. The study also found that chronic graft-versus-host disease (GVHD) and relapse were associated with worse survival outcomes in both MRD and MUD HSCT. Conclusion: This study supports the use of matched unrelated donor (MUD) transplant for HSCT in AML patients when a matched sibling donor is not available.