Sex differences in the medial prefrontal cortical glutamate system

Melissa C. Knouse; Anna G. McGrath; Andre U. Deutschmann; Matthew T. Rich; Lia J. Zallar; Anjali M. Rajadhyaksha; Lisa A. Briand

doi:10.1186/s13293-022-00468-6

Biology of Sex Differences (Nov 2022)

Sex differences in the medial prefrontal cortical glutamate system

Melissa C. Knouse,
Anna G. McGrath,
Andre U. Deutschmann,
Matthew T. Rich,
Lia J. Zallar,
Anjali M. Rajadhyaksha,
Lisa A. Briand

Affiliations

Melissa C. Knouse: Department of Psychology, Temple University
Anna G. McGrath: Department of Psychology, Temple University
Andre U. Deutschmann: Department of Psychology, Temple University
Matthew T. Rich: Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University
Lia J. Zallar: Department of Pharmacology, Weill Cornell Medicine of Cornell University
Anjali M. Rajadhyaksha: Pediatric Neurology, Pediatrics, Weill Cornell Medicine of Cornell University
Lisa A. Briand: Department of Psychology, Temple University

DOI: https://doi.org/10.1186/s13293-022-00468-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Highlights Female mice exhibit heightened synaptosomal expression of AMPAR subunits GluA1 and GluA2 in the mPFC compared to males. Females have enhanced glutamatergic transmission in the mPFC compared to males. There are baseline sex differences in the mPFC glutamate system that may underlie sex differences in the prevalence and presentation of certain psychiatric diseases.

Published in Biology of Sex Differences

ISSN: 2042-6410 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Physiology
Website: http://bsd.biomedcentral.com

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Abstract

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