Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Songtao Zhang; Longhai Jin; Jianhua Liu; Yang Liu; Tianqi Zhang; Ying Zhao; Na Yin; Rui Niu; Xiaoqing Li; Dongzhi Xue; Shuyan Song; Yinghui Wang; Hongjie Zhang

doi:10.1007/s40820-020-00516-z

Nano-Micro Letters (Sep 2020)

Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Songtao Zhang,
Longhai Jin,
Jianhua Liu,
Yang Liu,
Tianqi Zhang,
Ying Zhao,
Na Yin,
Rui Niu,
Xiaoqing Li,
Dongzhi Xue,
Shuyan Song,
Yinghui Wang,
Hongjie Zhang

Affiliations

Songtao Zhang: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Longhai Jin: Department of Radiology, The Second Hospital of Jilin University
Jianhua Liu: Department of Radiology, The Second Hospital of Jilin University
Yang Liu: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Tianqi Zhang: Department of Radiology, The Second Hospital of Jilin University
Ying Zhao: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Na Yin: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Rui Niu: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Xiaoqing Li: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Dongzhi Xue: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Shuyan Song: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Yinghui Wang: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
Hongjie Zhang: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)

DOI: https://doi.org/10.1007/s40820-020-00516-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Abstract In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

Published in Nano-Micro Letters

ISSN: 2311-6706 (Print); 2150-5551 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Technology
Website: http://www.springer.com/40820

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