Research progress on the association between Opa1 and diabetic cardiomyopathy

Abstract

Diabetic cardiomyopathy （DCM） refers to myocardial cell or cardiac microvascular injury and metabolic disorder caused by hyperglycemia alone. Studies have shown that DCM is closely associated with abnormal mitochondrial fusion. Optic atrophy 1 （Opa1） is one of the main proteins of mitochondrial fusion. Under hyperglycemia environment，the expression level of Opa1-1 is down-regulated，resulting in mitochondrial fusion disorder，which thereby leads to energy metabolism disorder，oxidative stress，increased insulin resistance，lipotoxicity and apoptosis，and finally causes DCM. Up-regulating the expression level of Opa1 can mitigate the symptoms of DCM. In this article，research progress in the correlation between Opa1 and DCM was reviewed，aiming to provide novel ideas for DCM research.

Keywords

• optic atrophy 1|mitochondrial fusion|diabetic cardiomyopathy|cardiomyocyte|pathogenesis|energy metabolism disorder|oxidative stress|insulin resistance and lipotoxicity|apoptosis