Sexual rejection via a vomeronasal receptor-triggered limbic circuit

Takuya Osakada; Kentaro K. Ishii; Hiromi Mori; Ryo Eguchi; David M. Ferrero; Yoshihiro Yoshihara; Stephen D. Liberles; Kazunari Miyamichi; Kazushige Touhara

doi:10.1038/s41467-018-07003-5

Nature Communications (Oct 2018)

Sexual rejection via a vomeronasal receptor-triggered limbic circuit

Takuya Osakada,
Kentaro K. Ishii,
Hiromi Mori,
Ryo Eguchi,
David M. Ferrero,
Yoshihiro Yoshihara,
Stephen D. Liberles,
Kazunari Miyamichi,
Kazushige Touhara

Affiliations

Takuya Osakada: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kentaro K. Ishii: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hiromi Mori: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Ryo Eguchi: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
David M. Ferrero: Department of Cell Biology, Harvard Medical School
Yoshihiro Yoshihara: ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo
Stephen D. Liberles: Department of Cell Biology, Harvard Medical School
Kazunari Miyamichi: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kazushige Touhara: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-018-07003-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Sex pheromones that increase mating have been reported across a number of different species, yet there is little known about pheromones that suppress female mating drive. This study reports that juvenile female mice release a pheromone, ESP22, which suppresses sexual receptivity of adult female mice by evoking a robust rejection behavior upon male mounting.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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