Nature Communications (May 2020)
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
- Katrin Fischer,
- Anna Fenzl,
- Dianxin Liu,
- Kenneth A. Dyar,
- Maximilian Kleinert,
- Markus Brielmeier,
- Christoffer Clemmensen,
- Anna Fedl,
- Brian Finan,
- Andre Gessner,
- Martin Jastroch,
- Jianfeng Huang,
- Susanne Keipert,
- Martin Klingenspor,
- Jens C. Brüning,
- Manfred Kneilling,
- Florian C. Maier,
- Ahmed E. Othman,
- Bernd J. Pichler,
- Ines Pramme-Steinwachs,
- Stephan Sachs,
- Angelika Scheideler,
- Wolfgang M. Thaiss,
- Henriette Uhlenhaut,
- Siegfried Ussar,
- Stephen C. Woods,
- Julia Zorn,
- Kerstin Stemmer,
- Sheila Collins,
- Maria Diaz-Meco,
- Jorge Moscat,
- Matthias H. Tschöp,
- Timo D. Müller
Affiliations
- Katrin Fischer
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Anna Fenzl
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Dianxin Liu
- Division of Cardiovascular Medicine, Vanderbilt University Medical Center
- Kenneth A. Dyar
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Maximilian Kleinert
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Markus Brielmeier
- Research Unit Comparative Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH
- Christoffer Clemmensen
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Anna Fedl
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Brian Finan
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Andre Gessner
- Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg
- Martin Jastroch
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Jianfeng Huang
- Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
- Susanne Keipert
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Martin Klingenspor
- Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan
- Jens C. Brüning
- Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
- Manfred Kneilling
- Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen
- Florian C. Maier
- Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen
- Ahmed E. Othman
- Department of Diagnostic and Interventional Radiology, Eberhard Karls University Hospital Tübingen
- Bernd J. Pichler
- Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen
- Ines Pramme-Steinwachs
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Stephan Sachs
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Angelika Scheideler
- Research Unit Comparative Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH
- Wolfgang M. Thaiss
- Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen
- Henriette Uhlenhaut
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Siegfried Ussar
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Stephen C. Woods
- Metabolic Disease Institute, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati
- Julia Zorn
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Kerstin Stemmer
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Sheila Collins
- Division of Cardiovascular Medicine, Vanderbilt University Medical Center
- Maria Diaz-Meco
- Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
- Jorge Moscat
- Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
- Matthias H. Tschöp
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- Timo D. Müller
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD)
- DOI
- https://doi.org/10.1038/s41467-020-16230-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.
