Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma

William M. Mendenhall, MD; Jonathan J. Beitler, MD, MBA; Nabil F. Saba, MD, FACP; Ashok R. Shaha, MD, FACS; Sandra Nuyts, MD, PhD; Primož Strojan, MD; Heleen Bollen, MD; Oded Cohen, MD; Robert Smee, MD; Sweet Ping Ng, MD; Avraham Eisbruch, MD; Wai Tong Ng, MD; Jessica M. Kirwan, MA; Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP

doi:10.14338/IJPT-22-00030.1

International Journal of Particle Therapy (Apr 2023)

Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma

William M. Mendenhall, MD,
Jonathan J. Beitler, MD, MBA,
Nabil F. Saba, MD, FACP,
Ashok R. Shaha, MD, FACS,
Sandra Nuyts, MD, PhD,
Primož Strojan, MD,
Heleen Bollen, MD,
Oded Cohen, MD,
Robert Smee, MD,
Sweet Ping Ng, MD,
Avraham Eisbruch, MD,
Wai Tong Ng, MD,
Jessica M. Kirwan, MA,
Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP

Affiliations

William M. Mendenhall, MD: 1 Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
Jonathan J. Beitler, MD, MBA: 2 Harold Alfonds Center for Cancer Care, Maine General Hospital, Augusta, ME, USA
Nabil F. Saba, MD, FACP: 3 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA
Ashok R. Shaha, MD, FACS: 4 Department of Head and Neck Surgery and Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Sandra Nuyts, MD, PhD: 5 Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven -University of Leuven, Leuven, Belgium
Primož Strojan, MD: 7 Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia
Heleen Bollen, MD: 5 Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven -University of Leuven, Leuven, Belgium
Oded Cohen, MD: 8 Department of Otolaryngology - Head and Neck Surgery and Oncology, Soroka Medical Center, Tel Aviv, Affiliated with Ben Gurion University of the Negev, Beer Sheva, Israel
Robert Smee, MD: 9 Department of Radiation Oncology, The Prince of Wales Cancer Centre, Sydney, NSW, Australia
Sweet Ping Ng, MD: 10 Department of Radiation Oncology, Olivia Newton-John Cancer Centre, Austin Health, Melbourne, Australia
Avraham Eisbruch, MD: 11 Department of Radiation Oncology, University of Michigan Medicine, Ann Arbor, Michigan, USA
Wai Tong Ng, MD: 12 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Jessica M. Kirwan, MA: 1 Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP: 13 Coordinator of the International Head and Neck Scientific Group, Padua, Italy

DOI: https://doi.org/10.14338/IJPT-22-00030.1
Journal volume & issue: Vol. 9, no. 4
pp. 243 – 252

Abstract

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Purpose: To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC). Materials and Methods: A review of the pertinent literature. Results: Proton beam therapy likely results in reduced acute and late toxicity as compared with intensity-modulated radiation therapy (IMRT). The extent of the reduced toxicity, which may be modest, depends on the endpoint and technical factors such as pencil beam versus passive scattered PBT and adaptive replanning. The disease control rates after PBT are likely similar to those after IMRT. Conclusion: Proton beam therapy is an attractive option to treat patients with OPSCC. Whether it becomes widely available depends on access.

Published in International Journal of Particle Therapy

ISSN: 2331-5180 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Science: Physics: Nuclear and particle physics. Atomic energy. Radioactivity
Website: https://www.sciencedirect.com/journal/international-journal-of-particle-therapy

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