Ventricular arrhythmias following coronary artery bypass grafting for ischemic cardiomyopathy: When to insert an implanted cardioverter defibrillator?Central MessagePerspective
Masaro Nakae, MD,
Satoshi Kainuma, MD, PhD,
Koichi Toda, MD, PhD,
Daisuke Yoshioka, MD, PhD,
Takuji Kawamura, MD, PhD,
Ai Kawamura, MD, PhD,
Noriyuki Kashiyama, MD, PhD,
Sho Komukai, PhD,
Tetsuhisa Kitamura, MD, MS, DPH,
Atsushi Hirayama, MD, MPH,
Yoshimitsu Shimomura, MD,
Kazuhiro Taniguchi, MD, PhD,
Shigeru Miyagawa, MD, PhD
Affiliations
Masaro Nakae, MD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Address for reprints: Masaro Nakae, MD,
Satoshi Kainuma, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Koichi Toda, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Daisuke Yoshioka, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Takuji Kawamura, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Ai Kawamura, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Noriyuki Kashiyama, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Sho Komukai, PhD
Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Tetsuhisa Kitamura, MD, MS, DPH
Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
Atsushi Hirayama, MD, MPH
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Yoshimitsu Shimomura, MD
Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
Kazuhiro Taniguchi, MD, PhD
Department of Cardiovascular Surgery, Higashiosaka City Medical Center, Higashiosaka, Osaka, Japan
Shigeru Miyagawa, MD, PhD
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Shigeru Miyagawa, MD, PhD, Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2-E1, Yamadaoka, Suita, Osaka 565-0871, Japan.
Objectives: The study objectives were to determine the incidence, predictors, and clinical impact of ventricular arrhythmias after coronary artery bypass grafting and to evaluate the impact of implantable cardioverter defibrillators on the survival of patients with ventricular arrhythmias. Methods: We enrolled 498 patients with a left ventricular ejection fraction of 40% or less who underwent coronary artery bypass grafting between 1993 and 2015. Clinical follow-up was completed in 94.0% of patients, with a median follow-up of 58.4 months. Results: Overall, 212 patients (43%) died, mainly of heart failure (n = 54, 10.8%) or sudden cardiac death (n = 40, 8.0%). The sudden cardiac death rate was highest during the first 6 months, with a monthly rate of 0.37%. Overall, 99 patients (20%) developed postoperative ventricular arrhythmias, and implantable cardioverter defibrillator was implanted in 55 patients. Previous ventricular arrhythmias (hazard ratio, 3.22; 95% confidence interval, 1.98-5.24; P < .001), left ventricular end-systolic dimension (hazard ratio, 1.07; 95% confidence interval, 1.04-1.10; P < .001), and myocardial infarction in the left anterior descending artery territory (hazard ratio, 1.73; 95% confidence interval, 1.10-2.73; P = .02) were independent predictors of postoperative ventricular arrhythmias. Notably, the 5-year survival of patients with ventricular arrhythmias who received an implantable cardioverter defibrillator was significantly higher than that of patients with ventricular arrhythmias who did not receive it (76.1% vs 22.7%, P < .001) and was comparable to that of patients without ventricular arrhythmias (76.1% vs 73.6%, P = .98). Conclusions: Sudden cardiac death affects a significant proportion of patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting, most frequently within 6 months postoperatively. To prevent sudden cardiac death, earlier implantable cardioverter defibrillator implantation should be indicated for high-risk patients with scars in the left anterior descending artery territory and excessive left ventricular remodeling.
