Nature Communications (Apr 2021)
Spatially interacting phosphorylation sites and mutations in cancer
- Kuan-lin Huang,
- Adam D. Scott,
- Daniel Cui Zhou,
- Liang-Bo Wang,
- Amila Weerasinghe,
- Abdulkadir Elmas,
- Ruiyang Liu,
- Yige Wu,
- Michael C. Wendl,
- Matthew A. Wyczalkowski,
- Jessika Baral,
- Sohini Sengupta,
- Chin-Wen Lai,
- Kelly Ruggles,
- Samuel H. Payne,
- Benjamin Raphael,
- David Fenyö,
- Ken Chen,
- Gordon Mills,
- Li Ding
Affiliations
- Kuan-lin Huang
- Department of Genetics and Genomics, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
- Adam D. Scott
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Daniel Cui Zhou
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Liang-Bo Wang
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Amila Weerasinghe
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Abdulkadir Elmas
- Department of Genetics and Genomics, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
- Ruiyang Liu
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Yige Wu
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Michael C. Wendl
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Matthew A. Wyczalkowski
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Jessika Baral
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Sohini Sengupta
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- Chin-Wen Lai
- Department of Pathology and Immunology, Washington University in St. Louis
- Kelly Ruggles
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- Samuel H. Payne
- Department of Biology, Brigham Young University
- Benjamin Raphael
- Lewis-Sigler Institute, Princeton University
- David Fenyö
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- Ken Chen
- Departments of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Gordon Mills
- Knight Cancer Institute, Oregon Health & Science University
- Li Ding
- Department of Medicine, McDonnell Genome Institute, Department of Genetics, Siteman Cancer Center, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-021-22481-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependencies in cancer.
