Acute Kidney Injury and Pediatric Bone Health

Anisha Hegde; Michelle R. Denburg; Dorey A. Glenn

doi:10.3389/fped.2020.635628

Frontiers in Pediatrics (Feb 2021)

Acute Kidney Injury and Pediatric Bone Health

Anisha Hegde,
Michelle R. Denburg,
Dorey A. Glenn

Affiliations

Anisha Hegde: Department of Pediatrics, University of North Carolina Hospitals, Chapel Hill, NC, United States
Michelle R. Denburg: Division of Nephrology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
Dorey A. Glenn: Division of Nephrology, University of North Carolina School of Medicine, Chapel Hill, NC, United States

DOI: https://doi.org/10.3389/fped.2020.635628
Journal volume & issue: Vol. 8

Abstract

Read online

Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism—including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho—its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

About the journal

Abstract

Keywords