Dose-dependent effects of mosapride citrate on duodenal and cecal motility in donkeys (Equus asinus)

Abstract

Prokinetic drugs are used for the management of gastrointestinal motility disorders in horses; however, little is known about their efficacy in donkeys. Therefore, the aim of the present study was to evaluate the effect of different doses of mosapride citrate on duodenal and cecal motility in normal donkeys. Six donkeys (n = 6) were used in a crossover study. Mosapride citrate was administered orally via a nasogastric tube at dose rate of 1, 2 and 3 mg kg−1. Duodenal and cecal motility were evaluated using ultrasonography before administration and at 15, 30, 60, 120 and 180 min post-administration. There was a significant increase of duodenal contractions (p < 0.05) after 30 min of mosapride citrate administration at 3 mg kg−1 with a prolonged (p < 0.05) prokinetic effect at 2 mg kg−1. Cecal contractions were significantly increased (p < 0.05) after 15 min at different doses of mosapride with a prolonged effect at 3 mg kg−1. The results of the present study indicate that mosapride citrate has a dose-dependent prokinetic effect on the duodenal and cecal contractions in healthy donkeys. Further studies need to determine whether mosapride citrate is effective in treatment of intestinal disorders in donkey.

Keywords

• Mosapride citrate
• Duodenum
• Caecum
• Ultrasonography
• Donkeys