Nature Communications (Jul 2020)

Immunological and inflammatory profiles in mild and severe cases of COVID-19

  • Jin-Wen Song,
  • Chao Zhang,
  • Xing Fan,
  • Fan-Ping Meng,
  • Zhe Xu,
  • Peng Xia,
  • Wen-Jing Cao,
  • Tao Yang,
  • Xiao-Peng Dai,
  • Si-Yu Wang,
  • Ruo-Nan Xu,
  • Tian-Jun Jiang,
  • Wen-Gang Li,
  • Da-Wei Zhang,
  • Peng Zhao,
  • Ming Shi,
  • Chiara Agrati,
  • Giuseppe Ippolito,
  • Markus Maeurer,
  • Alimuddin Zumla,
  • Fu-Sheng Wang,
  • Ji-Yuan Zhang

DOI
https://doi.org/10.1038/s41467-020-17240-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild.