AUTOPHAGY IN THE PATHOGENESIS OF TUBERCULOSIS

Abstract

Autophagy is an important immune mechanism defining the host resistance to intracellular pathogens and tuberculous mycobacteria in particular. Autophagy is involved into direct elimination of the pathogenic agent, control of immune reactions of the host and maintenance of intracellular homeostasis which is important for mycobacterial persistence. Inhibition of autophagy at the early stages of infection by virulent mycobacterial strains is one of the reasons of poor immune response, and mechanisms defining this response are considered to be promising field to search for approaches centered at the pathogen for the tuberculosis prevention and treatment.

Keywords

• аутофагия
• туберкулез
• интерферон-гамма
• витамин d3
• патогенетическая терапия