Unraveling NEAT1's complex role in lung cancer  biology

Md Sadique Hussain; Obaid Afzal; Gaurav Gupta; Ahsas Goyal; Waleed Hassan Almalki; Imran Kazmi; Sami I. Alzarea; Abdulmalik Saleh Alfawaz Altamimi; Neelam Kukreti; Amlan Chakraborty; Sachin Kumar Singh; Kamal Dua

doi:10.17179/excli2023-6553

EXCLI Journal : Experimental and Clinical Sciences (Jan 2024)

Unraveling NEAT1's complex role in lung cancer biology

Md Sadique Hussain,
Obaid Afzal,
Gaurav Gupta,
Ahsas Goyal,
Waleed Hassan Almalki,
Imran Kazmi,
Sami I. Alzarea,
Abdulmalik Saleh Alfawaz Altamimi,
Neelam Kukreti,
Amlan Chakraborty,
Sachin Kumar Singh,
Kamal Dua

Affiliations

Md Sadique Hussain: ORCiD; School of Pharmaceutical Sciences, Jaipur National University, Jagatpura 302017, Jaipur, India
Obaid Afzal: ORCiD; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia
Gaurav Gupta: ORCiD; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India. E-mail: [email protected]
Ahsas Goyal: ORCiD; Institute of Pharmaceutical Research, GLA University, Mathura, U. P., India
Waleed Hassan Almalki: ORCiD; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
Imran Kazmi: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Sami I. Alzarea: ORCiD; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia
Abdulmalik Saleh Alfawaz Altamimi: ORCiD; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia
Neelam Kukreti: ORCiD; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India
Amlan Chakraborty: ORCiD; Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.; Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia
Sachin Kumar Singh: ORCiD; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia
Kamal Dua: ORCiD; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia

DOI: https://doi.org/10.17179/excli2023-6553
Journal volume & issue: Vol. 23
pp. 34 – 52

Abstract

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This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

Published in EXCLI Journal : Experimental and Clinical Sciences

ISSN: 1611-2156 (Online)
Publisher: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General)
Website: http://www.excli.de

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Abstract

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