EXCLI Journal : Experimental and Clinical Sciences (Jan 2024)

Unraveling NEAT1's complex role in lung cancer biology

  • Md Sadique Hussain,
  • Obaid Afzal,
  • Gaurav Gupta,
  • Ahsas Goyal,
  • Waleed Hassan Almalki,
  • Imran Kazmi,
  • Sami I. Alzarea,
  • Abdulmalik Saleh Alfawaz Altamimi,
  • Neelam Kukreti,
  • Amlan Chakraborty,
  • Sachin Kumar Singh,
  • Kamal Dua

DOI
https://doi.org/10.17179/excli2023-6553
Journal volume & issue
Vol. 23
pp. 34 – 52

Abstract

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This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

Keywords