OncoTargets and Therapy (Apr 2024)
Traditional Chinese Medicine in Regulating Tumor Microenvironment
Abstract
Ziwei Wang, Mengyao Li, Ling Bi, Xueqing Hu, Yan Wang Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of ChinaCorrespondence: Yan Wang; Xueqing Hu, Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Rd528 Zhangheng, Shanghai, 201203, People’s Republic of China, Email [email protected]; [email protected]: Tumor microenvironment (TME) is a complex and integrated system containing a variety of tumor-infiltrating immune cells and stromal cells. They are closely connected with cancer cells and influence the development and progression of cancer. Traditional Chinese medicine (TCM) is an important complementary therapy for cancer treatment in China. It mainly eliminates cancer cells by regulating TME. The aim of this review is to systematically summarize the crosstalk between tumor cells and TME, and to summarize the research progress of TCM in regulating TME. The review is of great significance in revealing the therapeutic mechanism of action of TCM, and provides an opportunity for the combined application of TCM and immunotherapy in cancer treatment.Keywords: cancer, tumor microenvironment, traditional Chinese medicine, anti-tumor effects
