Nature Communications (Mar 2018)
Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4
- James J. Gilchrist,
- Anna Rautanen,
- Benjamin P. Fairfax,
- Tara C. Mills,
- Vivek Naranbhai,
- Holly Trochet,
- Matti Pirinen,
- Esther Muthumbi,
- Salim Mwarumba,
- Patricia Njuguna,
- Neema Mturi,
- Chisomo L. Msefula,
- Esther N. Gondwe,
- Jenny M. MacLennan,
- Stephen J. Chapman,
- Malcolm E. Molyneux,
- Julian C. Knight,
- Chris C. A. Spencer,
- Thomas N. Williams,
- Calman A. MacLennan,
- J. Anthony G. Scott,
- Adrian V. S. Hill
Affiliations
- James J. Gilchrist
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Anna Rautanen
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Benjamin P. Fairfax
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Tara C. Mills
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Vivek Naranbhai
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Holly Trochet
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Matti Pirinen
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Esther Muthumbi
- KEMRI-Wellcome Trust Research Programme
- Salim Mwarumba
- KEMRI-Wellcome Trust Research Programme
- Patricia Njuguna
- KEMRI-Wellcome Trust Research Programme
- Neema Mturi
- KEMRI-Wellcome Trust Research Programme
- Chisomo L. Msefula
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine
- Esther N. Gondwe
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine
- Jenny M. MacLennan
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine
- Stephen J. Chapman
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Malcolm E. Molyneux
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine
- Julian C. Knight
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Chris C. A. Spencer
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Thomas N. Williams
- KEMRI-Wellcome Trust Research Programme
- Calman A. MacLennan
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine
- J. Anthony G. Scott
- KEMRI-Wellcome Trust Research Programme
- Adrian V. S. Hill
- Wellcome Trust Centre for Human Genetics, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-017-02398-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in children and HIV-infected adults in Africa. Here, Gilchrist et al. conduct a genome-wide association study and show that genetic variation in STAT4 is a determinant of NTS in Kenyan and Malawian children.
