Nature Communications (Aug 2020)
Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
- Noam D. Beckmann,
- Wei-Jye Lin,
- Minghui Wang,
- Ariella T. Cohain,
- Alexander W. Charney,
- Pei Wang,
- Weiping Ma,
- Ying-Chih Wang,
- Cheng Jiang,
- Mickael Audrain,
- Phillip H. Comella,
- Amanda K. Fakira,
- Siddharth P. Hariharan,
- Gillian M. Belbin,
- Kiran Girdhar,
- Allan I. Levey,
- Nicholas T. Seyfried,
- Eric B. Dammer,
- Duc Duong,
- James J. Lah,
- Jean-Vianney Haure-Mirande,
- Ben Shackleton,
- Tomas Fanutza,
- Robert Blitzer,
- Eimear Kenny,
- Jun Zhu,
- Vahram Haroutunian,
- Pavel Katsel,
- Sam Gandy,
- Zhidong Tu,
- Michelle E. Ehrlich,
- Bin Zhang,
- Stephen R. Salton,
- Eric E. Schadt
Affiliations
- Noam D. Beckmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Wei-Jye Lin
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Minghui Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Ariella T. Cohain
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Alexander W. Charney
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Pei Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Weiping Ma
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Ying-Chih Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Cheng Jiang
- Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Mickael Audrain
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Phillip H. Comella
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Amanda K. Fakira
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Siddharth P. Hariharan
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Gillian M. Belbin
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Kiran Girdhar
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Allan I. Levey
- Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine
- Nicholas T. Seyfried
- Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine
- Eric B. Dammer
- Department of Biochemistry, Emory University School of Medicine
- Duc Duong
- Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine
- James J. Lah
- Department of Biochemistry, Emory University School of Medicine
- Jean-Vianney Haure-Mirande
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Ben Shackleton
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Tomas Fanutza
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Robert Blitzer
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Eimear Kenny
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Jun Zhu
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Vahram Haroutunian
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Pavel Katsel
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Sam Gandy
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Zhidong Tu
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Michelle E. Ehrlich
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Bin Zhang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Stephen R. Salton
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-020-17405-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.
