Everolimus in Erdheim-Chester disease

Abstract

A 43-year-old man presented with bony pains, repeated pathological fractures with overlying skin ulcerations, and forearm and chest wall swellings. Investigations led to the diagnosis of Erdheim-Chester disease. Treatment with low-dose prednisolone, oral everolimus, and zoledronic acid was started, with a marked improvement in his condition.

Keywords

• Erdheim-Chester disease, everolimus, lipid-storing histiocytosis, pathological fractures, Touton giant cells