Nature Communications (Nov 2017)
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
- Shin-Ichiroh Saitoh,
- Fumiko Abe,
- Atsuo Kanno,
- Natsuko Tanimura,
- Yoshiko Mori Saitoh,
- Ryutaro Fukui,
- Takuma Shibata,
- Katsuaki Sato,
- Takeshi Ichinohe,
- Mayumi Hayashi,
- Kazuishi Kubota,
- Hiroko Kozuka-Hata,
- Masaaki Oyama,
- Yorifumi Kikko,
- Toshiaki Katada,
- Kenji Kontani,
- Kensuke Miyake
Affiliations
- Shin-Ichiroh Saitoh
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Fumiko Abe
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Atsuo Kanno
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Natsuko Tanimura
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Yoshiko Mori Saitoh
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Ryutaro Fukui
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Takuma Shibata
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Katsuaki Sato
- Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
- Takeshi Ichinohe
- Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo
- Mayumi Hayashi
- Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai
- Kazuishi Kubota
- Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai
- Hiroko Kozuka-Hata
- Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo
- Masaaki Oyama
- Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo
- Yorifumi Kikko
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Toshiaki Katada
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Kenji Kontani
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Kensuke Miyake
- Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-017-01687-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.
