The effect of Hydroethanolic Extract of Tragopogon Pratensis L. leaves on T3, T4 and TSH Serum Levels in Male Rats Induced with Lead Acetate

Abstract

    Background & aim:  Thyroid hormones play an important role in controlling and maintaining homeostasis. In this study, the effect of Tragopogon pratensis L.) was investigated on serum thyroid hormones levels in rats receiving acetate. Methods: In this experimental study, 36 male rats were divided into 6 groups including control, lead acetate and treatment groups 1, 2 and 3 (lead acetate + extract of Tragopogon pratensis L. at doses of 200, 400 and a high dose of 800 mg / kg) and the positive control group receiving Tragopogon pratensis L. extract (400 mg / kg dose). At the end of the experiments, after anesthesia, blood samples were taken from the heart of the animals and the serum levels of thyroid hormones TSH, T4, and T3 were measured. Data were analyzed using ANOVA and Tukey tests. Results: A Significant decreases were seen in serum levels of T3, T4 and TSH in the acetate receiving groups decreased significantly compared to the control group (p <0.001). But  the treated groups with Tragopogon pratensis L. extract significantly increased serum levels of thyroid hormones compared to those receiving acetate.  Conclusion: Hydroalcoholic extract of Sheng increased thyroid hormones to normal levels in lead acetate receiving mice. It is believed that the chemical compounds present in the extract of this plant can protect the thyroid tissue against the destructive effects of lead acetate.    

Keywords

• Lead acetate
• Thyroid Hormones
• Rat
• Tragopogon pratensis